Preparation of 6 hydroxy-7-deoxytaxanes using nocardioides luteu

Details Preparation of 6 hydroxy-7-deoxytaxanes using nocardioides luteu Preparation of 6 hydroxy-7-deoxytaxanes using nocardioides luteu

1999-01-14

2000-12-19

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435117, 435195, C12P 1702

Patent

active

061626228

ABSTRACT:
An enzymatic hydroxylation method for the preparation of compounds useful as intermediates in the preparation of taxanes such as 6-.alpha.-hydroxy-7-deoxypaclitaxel, wherein one or more C-6 hydrogen-bearing taxanes are contacted with an enzyme or microorganism capable of hydroxylating said C-6 carbon to give C-6 hydroxyl-bearing taxane.

REFERENCES:
patent: 5516676 (1996-05-01), Hanson
patent: 5523219 (1996-06-01), Hanson
patent: 5739016 (1998-04-01), Hanson

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