Preparation of 6,6-dibromo-penicillanic acid-1,1-dioxide

Details Preparation of 6,6-dibromo-penicillanic acid-1,1-dioxide Preparation of 6,6-dibromo-penicillanic acid-1,1-dioxide

1984-10-10

1986-03-18

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D49900, A61K 31425

Patent

active

045767548

ABSTRACT:
In a process for the preparation of 6,6-dibromo-penicillanic acid-1,1-dioxide comprising reacting 6.beta.-amino-penicillanic acid-1,1-dioxide with a nitrosating agent in the presence of bromine and an inorganic acid or strong organic acid, the improvement comprising effecting the reaction in the presence of an alcohol resulting in a high purity product.

REFERENCES:
patent: 4397783 (1983-08-01), Kellogg
patent: 4420426 (1983-12-01), Moore
patent: 4432970 (1984-02-01), Kellogg
Jour. of Org. Chemistry, vol. 27, pp. 1693-2710, (1962).
Jour. of the Chem. Soc., 1821-2832 (1969) (London).

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