Preparation of 5-hydroxymethylimidazoles

Details Preparation of 5-hydroxymethylimidazoles Preparation of 5-hydroxymethylimidazoles

1980-02-08

1981-07-14

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548335, 548346, C07D23364

Patent

active

042788013

ABSTRACT:
A process for the manufacture of 5-hydroxymethylimidazoles by reaction of an imidazole with formaldehyde or an oligomer of formaldehyde in aqueous hydrochloric acid solution containing from 5 to 18% by weight of hydrogen chloride, at from 80.degree. to 160.degree. C., if desired in a closed system under pressure, followed by isolation in the form of its hydrochloride of the 5-hydroxymethylimidazole obtained.

REFERENCES:
Mathieu, J., et al., Formation of C--C Bonds, Georg Thieme, Stuttgart, 1973, pp. 4-10.
Ewins, J. Chem. Soc., 99, 2055 (1911).
Durant, G., et al., J. Med. Chem., 19, 923-928, (1976).
Chemical Abstracts, 82: 43347d (1975), [Masui et al., Chem. Pharm. Bull. 22, 2359 (1974)].
Chemical Abstracts, 78: 58317k, (1973), [Godefrol et al., Rec. Trav. Chim., 91, 1383, (1972)].
Gordon, A., et al., The Chemist's Companion, John Wiley, New York, 1972, p. 77.
Chemic 7: 1871 (1913), [Wellisch, J., Biochem. 2, 49, 173-194 (1913)].

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