Preparation of 4-hydroxymethyltetrahydropyrans

Details Preparation of 4-hydroxymethyltetrahydropyrans Preparation of 4-hydroxymethyltetrahydropyrans

1992-12-14

1993-10-12

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30906

Patent

active

052527557

ABSTRACT:
A process for the preparation of 4-hydroxymethyltetrahydropyrans of the formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen, C.sub.1 - to C.sub.12 -alkyl, C.sub.3 - to C.sub.8 -cycloalkyl, aryl or C.sub.7 - to C.sub.20 -aralkyl, comprises reacting a tetrahydropyrancarboxylic ester of the formula II ##STR2## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, and R.sup.5 is hydrogen or C.sub.1 - to C.sub.12 -alkyl, at from 50.degree. to 400.degree. C. and at from 1 to 400 bar in the presence of hydrogen and a hydrogenation catalyst.

REFERENCES:
patent: 2479283 (1949-08-01), Whetstone
patent: 3124599 (1964-03-01), Guest et al.
patent: 3187012 (1965-06-01), Dunlop et al.
Chem. Abst., vol. 105, No. 17, Oct. 27, 1986, Abst. No. 152925e.
Rastether, JACS, 98, 6350-53 (1976).

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