Preparation of 4-bromo-o-xylene in liquid sulfur dioxide

Details Preparation of 4-bromo-o-xylene in liquid sulfur dioxide Preparation of 4-bromo-o-xylene in liquid sulfur dioxide

1990-02-22

1991-06-25

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Halogen containing

570207, 570209, C07C 1712

Patent

active

050269321

ABSTRACT:
A regioselective process is provided for preparing 4-bromo-o-xylene in an isomer mixture of 4-bromo-o-xylene and 3-bromo-o-xylene by combining bromine with o-xylene in liquid sulfur dioxide medium. A bromine to o-xylene mole ratio of about 0.4:1 to about 1:1 is utilized at a temperature in the range of about -20.degree. C. to about 40.degree. C. While preferred temperatures are in the about -15.degree. C. to about -9.degree. C. range, temperatures above about -9.degree. C. can be used by maintaining the reactant solution under pressure. A product isomer mixture can be isolated by vacuum distillation. A 92:8 weight ratio mixture of 4-bromo-o-xylene and 3-bromo-o-xylene is thus obtainable.

REFERENCES:
patent: 2452154 (1948-10-01), Ross
patent: 3932542 (1976-06-01), Gerns
Meirovics et al., "Chemical Abstracts" vol. 74 (1971) 42032v.
Canselier, Bull. Soc. Chim. France (1972) pp. 762-764.
Canselier, Bull. Soc. Chim. France (1971) pp. 1785 and 1788.

Affiliated with

Also associated with

Rating

Preparation of 4-bromo-o-xylene in liquid sulfur dioxide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of 4-bromo-o-xylene in liquid sulfur dioxide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of 4-bromo-o-xylene in liquid sulfur dioxide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1041783