Preparation of 4-(6'-methoxy-2'-naphthyl)-3-buten-2-one

Details Preparation of 4-(6'-methoxy-2'-naphthyl)-3-buten-2-one Preparation of 4-(6'-methoxy-2'-naphthyl)-3-buten-2-one

1988-06-17

1993-07-06

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568318, C07C 4545

Patent

active

052256030

ABSTRACT:
An intermediate for the manufacture of nabumetone, 4-(6'-methoxy-2'-naphthyl)-3-buten-2-one, is prepared by contacting 2-bromo-6-methoxynaphphalene with methyl vinyl ketone in the presence of a palladium catalyst at from about 50.degree. C. to about 200.degree. C. for a time sufficient to cause substantially complete reaction to occur.

REFERENCES:
patent: 4061779 (1977-12-01), Lake et al.
patent: 4221741 (1980-09-01), Gaster
Cacchi et al, J. Org. Chem, vol. 48, pp. 4236-4240 (1983).
Heck, Pure & Applied Chem, vol. 50, pp. 691-701 (1978).
Melpolder et al, J. Org. Chem., vol. 41, pp. 265-272 (1976).
Chalk et al, J. Org. Chem, vol. 41, pp. 273-278 (1976).
Chalk et al, J. Org. Chem, vol. 41, pp. 1206-1209 (1976).
Cacchi et al, Synthesis, #7, pp. 575-577 (1984).

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