Preparation of 4(5)-nitroimidazole-5(4)-carboxylic acids

Details Preparation of 4(5)-nitroimidazole-5(4)-carboxylic acids Preparation of 4(5)-nitroimidazole-5(4)-carboxylic acids

1987-11-30

1989-02-07

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23391

Patent

active

048032832

ABSTRACT:
4(5)-nitroimidazole-5(4)-carboxylic acids are prepared by reacting an imidazole-4(5)-carboxylic acid with a mixture of sulfuric acid and nitric acid at not less than 80.degree. C., the water content of the reaction mixture at the beginning of the reaction being no higher than 5% by weight, based on the reaction mixture.

REFERENCES:
patent: 4145553 (1979-03-01), Wetzler et al.
K. Hofmann, "The Chemistry of Heterocyclic Compounds", "Imidazole and Its Derivatives", Part I, 1953, p. 123.
J. Chem. Society, 115, 217-236 (1919).
Ca 51, 17897a, 1957.
Chem. Abstracts 82, 72,869f (1975).
Heterocyclic Compounds, vol. 5, p. 208, lines 5-10 (1957).
Chem. Abstracts 51, 1897a (1957).
Hofmann, Imidazole and Its Derivatives, Part I, Interscience Publishers, Inc. NY, (1953) p. 127.

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