Preparation of 3-[z-benzoxazol-2-yl)ethyl]-5-(1-hydroxyethyl)-6-

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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C12P 1716

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053875125

ABSTRACT:
Incubation of ##STR1## with a preparation from mammalian organ yields as biotransformation product the compound 3-[2-(benzoxazol-2-yl)ethyl]-5-(1-hydroxyethyl)-6-methyl-2-(1H)-pyridinone . This product is useful in the prevention or treatment of infection by HIV and the treatment of AIDS.

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Goldman, M. E. et al., "Pyridinone derivatives: Specific HIV-1 reverse transcriptase inhibitors with antiviral activity," Proc. Nat. Acad. Sci. 88, 6863 (1991).

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