Preparation of (3-trifluoromethylphenoxy)(4-chlorophenyl)acetoni

Details Preparation of (3-trifluoromethylphenoxy)(4-chlorophenyl)acetoni Preparation of (3-trifluoromethylphenoxy)(4-chlorophenyl)acetoni

1974-11-12

1976-04-27

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260453R, 260473G, 424308, C07C12166

Patent

active

039534901

ABSTRACT:
A method for preparing 2-acetamidoethyl (3-trifluoromethylphenoxy)(4-chlorophenyl)acetate which comprises treating (3-trifluoromethylphenoxy)(4-chlorophenyl)acetonitrile with 2-acetamidoethanol in the presence of an acid to form an imino intermediate which, upon treatment with an aqueous solution, affords the desired product. 2-Acetamidoethyl (3-trifluoromethylphenoxy)(4-chlorophenyl)acetate is a hypocholesterolemic and hypolipemic agent which effectively reduces the concentration of cholesterol, triglycerides and other lipids in blood serum.

REFERENCES:
patent: 3816446 (1974-06-01), Bolhofer
asthana et al.: Indian J. Chem., Vol. 8, pp. 1086-1095 (1970).

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