Preparation of 3-substituted cephalosporins

Details Preparation of 3-substituted cephalosporins Preparation of 3-substituted cephalosporins

1980-05-01

1981-11-17

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548153, 424246, 544111, C07D50120, C07D27760

Patent

active

043012809

ABSTRACT:
There is described a process for preparing an enamine of formula (IX): ##STR1## where R.sup.2 is a carboxylic acid protecting group and R.sup.3 is the residue of a carboxylic acid derived acyl group and where R.sup.5 and R.sup.6 are the same or different C.sub.1-4 alkyl or C.sub.7-10 aralkyl groups; or taken together with the adjacent nitrogen atom form a heterocyclic ring containing from 4 to 8 carbon atoms and optionally a further heteroatom selected from oxygen and nitrogen; by reacting a compound of formula (XII): ##STR2## with an amine of formula HNR.sup.5 R.sup.6, the reactant of formula (XII) being prepared by reaction of an appropriate enol derivative with a phosphorus reagent. The enamines of formula (IX) are useful in the preparation of 3-hydroxycephalosporins.

REFERENCES:
patent: 4079181 (1978-03-01), Tsuji et al.
patent: 4160085 (1979-07-01), Tsuji et al.
patent: 4226986 (1980-10-01), Hatfield et al.

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