Preparation of 3-hydroxy-3-phenylbutan-2-one

Details Preparation of 3-hydroxy-3-phenylbutan-2-one Preparation of 3-hydroxy-3-phenylbutan-2-one

1986-06-02

1987-11-03

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 4571

Patent

active

047044756

ABSTRACT:
A process is provided for preparing 3-hydroxy-3-phenyl-butan-2-one, useful in the preparation of acifran, in high yields by reacting 2,3-butanedione with the appropriate Grignard reagent at low temperature in tetrahydrofuran or admixtures thereof with toluene.

REFERENCES:
patent: 2921940 (1960-01-01), Ramsden
Lapkin et al., J. Gen. Chem. U.S.S.R., vol. 19, pp. 669-675 (1949).
Kask et al., Chem. Abst., vol. 69, #35114a (1968).
Taulmets, Chem. Abst., vol. 82, #42803n (1975).
Trost et al., J. Org. Chem., vol. 45, pp. 2741-2746 (1980).
Lapkin and Golovkova, Zuhr. Obshchei Khim (J. Gen. Chem.) 19,701-6 (1949) Abstracted in Chemical Abstracts 44,1057h (1950).
Beilstein's Handbook (1969) at page 458.

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