Preparation of 3-bromo-4-fluoro-benzoic acid

Details Preparation of 3-bromo-4-fluoro-benzoic acid Preparation of 3-bromo-4-fluoro-benzoic acid

1981-09-02

1983-07-12

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5129

Patent

active

043932320

ABSTRACT:
A process for the preparation of 3-bromo-4-fluorobenzoic acid of the formula ##STR1## comprising reacting fluorobenzene of the formula ##STR2## acetyl chloride in the presence of an acylation catalyst at a temperature from about 0.degree. to 100.degree. C., reacting the reaction mixture thereby obtained with bromine at a temperature from about 50.degree. to 150.degree. C., separating the resulting bromination product and reacting it with hypochlorite solution at a temperature between about 0.degree. and 100.degree. C. Aluminum chloride is the preferred catalyst.

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N. N. Quang et al., Rec. Trav. Chim., Pay Bas 83, 1142-1148 (1964).

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