Preparation of 3-amino-1-hydroxypropane-1, 1-diphosphonic acid

Details Preparation of 3-amino-1-hydroxypropane-1, 1-diphosphonic acid Preparation of 3-amino-1-hydroxypropane-1, 1-diphosphonic acid

1997-08-13

1998-08-11

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

C07F 938

Patent

active

057928851

ABSTRACT:
A preparation of 3-amino-1-hydroxypropane-1,1-diphosphonic acid includes the steps of: mixing N-alkoxycarbonyl-.beta.-alanine, phosphorous chloride and phosphorous acid in the ratio of 1:1:1.about.1:3:3 in a reaction solvent, xylene at 70.degree.-140.degree. C.; hydrolyzing; and obtaining 3-amino-1-hydroxypropane-1,1-diphosphonic acid as a product, thus decreasing the production of unidentified by-products and giving and low production cost by using xylene instead of chlorobenzene as a reaction solvent.

REFERENCES:
patent: 4304734 (1981-12-01), Jary et al.
patent: 4719203 (1988-01-01), Bosies et al.
patent: 4927814 (1990-05-01), Gall et al.
patent: 5019651 (1991-05-01), Kieczykowski et al.

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