Preparation of 3-alkylthiomethyl cephalosporins

Details Preparation of 3-alkylthiomethyl cephalosporins Preparation of 3-alkylthiomethyl cephalosporins

1973-10-23

1976-03-02

Gallagher, Richard J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602391, 424246, 424271, C07D50104

Patent

active

039417816

ABSTRACT:
This invention is addressed to a new and improved method for the preparation of 3-alkylthiomethyl-7-acylamido cephalosporins in which a 3-alkanoyloxymethyl-7-acylamido cephalosporin is reacted with an alkane thiol in aqueous medium in the presence of certain inorganic salts to produce the desired 3-alkylthiomethyl product in significantly improved yields.

REFERENCES:
patent: 3830808 (1974-08-01), Clark et al.

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