Preparation of 3,4-difluorobenzoic acid by the decarboxylation o

Details Preparation of 3,4-difluorobenzoic acid by the decarboxylation o Preparation of 3,4-difluorobenzoic acid by the decarboxylation o

1989-11-20

1990-06-26

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 538

Patent

active

049373773

ABSTRACT:
4,5-Difluorphthalic anhydride and 4,5-difluorophthalic acid may be decarboxylated in high yield to 3,4-difluorobenzoic acid by heating in N-methyl-2-pyrrolidone or dimethyl acetamide using copper, copper oxide, copper salts, or halides and salts of Zn, Cd, Ag and Ni as a catalyst.

REFERENCES:
Strong, L. et al., J. Solution Chem. 16(2) 105-24 1987.
Rossiter, J. et al., Tehaherdron Lett. 28(43) 5173-4 1987.
C. Wang, Bul. Inst. Kim. Acad. Sinica No. 2156 (1972) (Abstr. CA79 (15):91729) Yakobson, OJ, ZH. Obsch. Khim 36 (1966) pp. 139 (in J. Gen. Chem. USSR, (translated from Russian), 36, (1966) pp. 144.

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