Preparation of 20-keto-.DELTA..sup.16 -steroids

Details Preparation of 20-keto-.DELTA..sup.16 -steroids Preparation of 20-keto-.DELTA..sup.16 -steroids

1984-04-27

1985-11-05

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039747, 2603973, 26039745, C07J 500

Patent

active

045512787

ABSTRACT:
A novel process for the preparation of 20-keto-.DELTA..sup.16 -steroids comprising reacting a 17-(isocyanosulfonylmethylene)-steroid with an alkylating agent QR.sub.4 wherein R.sub.4 is an organic group and Q is a group or atom readily displaced with a nucleophile to form a 20-isocyano-20-sulfonyl-.DELTA..sup.16 -steroid followed by hydrolysis which are intermediates for the preparation of corticosteroids and the novel intermediates formed therein.

REFERENCES:
patent: 3944584 (1976-03-01), Chao et al.
patent: 4496720 (1985-01-01), Bruynes et al.

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