Preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine

Details Preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine Preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine

1989-08-15

1990-04-17

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23942

Patent

active

049181912

ABSTRACT:
In an improved process for the preparation of 2-n-propyl-4-amino-5-methoxymethyl-pyrimidine of the formula I ##STR1## by reacting butyramidine II ##STR2## with .alpha.-methoxymethyl-.beta.-methoxyacrylonitrile III ##STR3## the butyramidine II is reacted with a 0.4-5 molar excess of .alpha.-methoxymethyl-.beta.-methoxyacrylonitrile III at from -10.degree. to +20.degree. C.

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