Preparation of 2-keto carboxylic acid from carbon dioxide

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

Reexamination Certificate

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C435S136000, C435S189000, C435S191000, C435S232000

Reexamination Certificate

active

07015020

ABSTRACT:
The invention discloses a novel method for the preparation of a 2-keto carboxylic acid from carbon dioxide by an enzymatic addition reaction with an aldehyde compound. Carbon dioxide, which can be in the form of carbonate ions, is reacted with an aldehyde compound such as acetaldehyde and propionaldehyde under mild reaction conditions in the presence of a decarboxylase to give a 2-keto carboxylic acid such as pyruvic and a 2-ketobutyric acid by a reverse reaction to the enzymatic decarboxylation reaction. The scope of the invention involves contribution to a solution of the environmental problem of global warming due to carbon dioxide as a greenhouse effect gas in the aerospace.

REFERENCES:
patent: 5631143 (1997-05-01), Menart et al.
Foppen, et al., Recl. Trav. Chim. Pays-Bas, vol. 109, No. 5, pp. 359-360 (1991).
Miyazaki, et al., Chemical Communiations, vol. 18, pp. 1800-1801, (Aug. 2001) Cambridge, United Kingdom.
Wiesser, et al., Journal of Molecular Catalysis B Enzymatic, vol. 11, No. 4-6, pp. 179-184, (2001).

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