Preparation of 2-choloro-4,5-difluorobenzoic acid from 4,5-diflu

Details Preparation of 2-choloro-4,5-difluorobenzoic acid from 4,5-diflu Preparation of 2-choloro-4,5-difluorobenzoic acid from 4,5-diflu

1990-06-04

1991-03-26

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5138

Patent

active

050031031

ABSTRACT:
2-Chloro-4,5-difluorobenzoic acid may be prepared by decarboxylating 4,5-difluorophthalic anhydride or 4,5-difluorophthalic acid by heating in N-methyl-2-pyrrolidone or dimethyl acetamide optionally using copper, copper oxide, copper salts, or halides or salts of Zn, Cd, Ag and Ni as a catalyst to form 3,4-difluorobenzoic acid, reacting said 3,4-difluorobenzoic acid with a mixture of nitric and sulfuric acids to form 2-nitro-4,5-difluorobenzoic acid, reacting said 2-nitro-4,5-difluorobenzoic acid with elemental chlorine at a temperature of between 185.degree. and 195.degree. C. to form 2-chloro-4,5-difluorobenzoic acid.

REFERENCES:
patent: 1956718 (1934-05-01), Jaeger
patent: 4935541 (1990-06-01), O'Reilly

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