Preparation of 2-(Chloromethyl)pyridine

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D21326

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042219132

ABSTRACT:
2-(Chloromethyl)pyridine is prepared by the reaction of 2-methylpyridine-N-oxide with phosgene (carbonyl chloride) in the presence of a solvent and an acid acceptor.

REFERENCES:
Abramovitch, Pyridine and its Derivatives, Supplement, Part Two, Wiley-Interscience, p. 457 (1974).
Matsumura, Chem. Abstracts, vol. 48, No. 11, p. 6442(b), Jun. 10, 1954.
Kato, Chem. Abstracts, vol. 50, No. 12, 8664-c to 8666-b (Jun. 25, 1956).

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