Preparation of 2-chloro-5-methylpyridine

Details Preparation of 2-chloro-5-methylpyridine Preparation of 2-chloro-5-methylpyridine

1984-03-14

1986-09-16

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21172

Patent

active

046123776

ABSTRACT:
A 2-oxo-5-methyl-5,6-dihalopiperidine is contacted in a high boiling solvent, preferably trichlorobenzene, with a stoichiometric excess, up to 70 mole % excess, of a chlorinating agent, preferably phosphorus oxychloride or phosgene, at an elevated temperature between 80.degree. and 130.degree. C. The solution of 2-chloro-5-methylpyridine so obtained may be used directly for further chlorination to form 2-chloro-5-trichloromethylpyridine with, for example, chlorine gas in the presence of a free radical initiator. This chemical intermediate is useful in the synthesis of certain herbicidal compounds.

REFERENCES:
patent: 3123608 (1964-03-01), Mathes et al.
patent: 4205175 (1980-05-01), Bowden et al.
patent: 4473696 (1984-09-01), Hartmann et al.

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