Preparation of 2-chloro-4-fluorophenol from 4-fluorophenol

Details Preparation of 2-chloro-4-fluorophenol from 4-fluorophenol Preparation of 2-chloro-4-fluorophenol from 4-fluorophenol

1985-03-07

1986-10-28

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568774, 568779, C07C 3927

Patent

active

046200428

ABSTRACT:
2-Chloro-4-fluorophenol is obtained with good yield by direct chlorination of 4-fluorophenol with chlorine gas at 0.degree.-185.degree. C. in the absence of catalyst. In a combination of these reactants, the selectivity to the substitution chlorination reaction at the 2-position of 4-fluorophenol is uncommonly high and reaches about 99% under optimum conditions. 4-Fluorophenol is subjected to the reaction as either pure liquid or solution in a suitable organic solvent such as carbon tetrachloride or acetic acid.

REFERENCES:
patent: 1847566 (1932-03-01), Laschinger
patent: 2659759 (1953-11-01), Zemba
patent: 2759981 (1956-08-01), Pray et al.
patent: 3318949 (1967-05-01), Roberts et al.
patent: 4489210 (1984-12-01), Judat et al.
Groves, et al, The Scission of Diaryl Ethers and Related Compounds by Means of Piperidine, Part II., The Nitration of 2:4:4'-Trichlorodiphenyl Ether, and of 2:4 Dichlorophenyl p-Toluenesulphonate and Benzoate, Journal of the Chemical Society, London, 1929, p. 516.
J. Am. Chem. Soc., 81,94-101, (1959).
U.S.S.R. Pat. No. 154,250, (Chem. Abstr., 2835 (1963)).
Zhurnal Obshchei Khimii, 27, 2486-87 (1967) (Chem. Abstr., vol. 68, 114200z (1968)).

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