Preparation of 2-aryl-2-hydroxyiminoacetic acids (syn isomers)

Details Preparation of 2-aryl-2-hydroxyiminoacetic acids (syn isomers) Preparation of 2-aryl-2-hydroxyiminoacetic acids (syn isomers)

1974-02-14

1976-05-25

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260295R, 260307R, 2603473, 260516, 260518A, 260519, C07D33324

Patent

active

039593142

ABSTRACT:
2-Aryl-2-hydroxyiminoacetic acids rich in the syn isomer are prepared by reaction of an arylglyoxylic acid with hydroxylamine in an aqueous reaction medium, e.g. water, in the presence of a source of magnesium, calcium or zinc ions, e.g. magnesium hydroxide. The acids so obtained are of value as synthetic intermediates in the preparation of penicillin and cephalosporin antibiotics containing syn-2-aryl-2-hydroxyiminoacetamido side chains.

REFERENCES:
edge et al., "Chemical Abstracts," p. 77108w, Vol. 70, (1969).
Ahmad et al., "Canadian J. Chemistry," 39, 1340 (1961).

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