Preparation of 2-alkylsulphonylalkylenepyrimidines

Details Preparation of 2-alkylsulphonylalkylenepyrimidines Preparation of 2-alkylsulphonylalkylenepyrimidines

1986-10-02

1988-06-28

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23932, C07D23934, C07D23946

Patent

active

047540354

ABSTRACT:
A process for the preparation of a 2-alkylsulphonylalkylenepyrimidine optionally substituted in 5- and/or 6-positions of the formula ##STR1## comprising (1) reacting an ammonium halide, alkylmercaptan and chloroalkylenenitrile in the presence of an acid acceptor; (2) mixing an ester with an alkyl acetate in the presence of an alcoholic alcoholate solution and an inert diluent; mixing (1) and (2); after completion of reaction removing the alcohol; adding water and an acid to the residue; optionally concentrating the mixture; and, without further purification and/or isolation, reacting the mixture with hydrogen peroxide at a temperature between approximately -20.degree. C. and +100.degree. C. in the presence of a catalytic amount of a vanadium, tungsten or molybdenum salt, in the presence of water as a diluent.

REFERENCES:
patent: 4234587 (1980-11-01), Maurer et al.
patent: 4323571 (1982-04-01), Maurer et al.
patent: 4503057 (1985-03-01), Maurer et al.

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