Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates

Details Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates

1989-10-18

1991-07-30

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548412, 548501, 548531, 548539, 548453, 548542, 540556, 540567, 540569, C07D20712, C07D47108, C07D207408, B01J 3124

Patent

active

050361538

ABSTRACT:
(R,R)-2,5-Diazabicyclo[ 2.2.1]heptanes are prepared from a compound of the formula ##STR1## wherein X and R.sub.2 are as defined herein, by heating with tosylchloride in pyridine, reacting the formed compound of the formula ##STR2## with a C.sub.1 -C.sub.6 alkylamine or ammonia, and reducing or hydrolyzing the formed compound of the formula ##STR3## wherein R.sub.1 is hydrogen or C.sub.1 -C.sub.6 alkyl.

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