Preparation of 2-(4-hydroxyphenoxy) propionates

Details Preparation of 2-(4-hydroxyphenoxy) propionates Preparation of 2-(4-hydroxyphenoxy) propionates

1996-09-06

1999-03-23

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 67, C07C 6976

Patent

active

058862099

ABSTRACT:
A multi-stage catalytic process for preparing a 2-(4-hydroxyphenoxy)-propionate, especially methyl 2-(4-hydroxyphenoxy)-propionate, with a purity greater than 99% by esterifying the corresponding 2-(4-hydroxyphenoxy)-propionic acid with an excess amount of alcohol, e.g. methyl alcohol, in a series of at least 2 up to 10 sequential stages at temperatures of 20.degree. to 150.degree. C. and pressures of 0.05 to 5 bar in the presence of a distillable acid catalyst such as hydrochloric acid or hydrogen chloride. In a first esterification stage, unreacted alcohol is removed from the ester product in vacuo at temperatures of 30.degree. to 100.degree. C. together with other volatile components, including the acid catalyst. Without a separate purification of the resulting ester as the bottoms product of the first stage, the esterification step is repeated in at least one additional stage. The final ester product of this multi-stage process is characterized by a water content of less than 0.1%, a halide content of less than 100 ppm, an organic halogen content of less than 50 ppm and a content of all other contaminating compounds of less than 0.1%.

REFERENCES:
patent: 4547583 (1985-10-01), Nestler
Morrison and Boyd 3rd edition "Organic Chemistry" 1975 pp. 602-603.
Beilstein BRN 2720530-Record -#1 , 1981 Kuchan, Collect. Czech. Chem. Commun-1.

Affiliated with

Also associated with

Rating

Preparation of 2-(4-hydroxyphenoxy) propionates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of 2-(4-hydroxyphenoxy) propionates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of 2-(4-hydroxyphenoxy) propionates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2127224