Preparation of 2,4,6-trimethylbenzoic acid

Details Preparation of 2,4,6-trimethylbenzoic acid Preparation of 2,4,6-trimethylbenzoic acid

1993-01-28

1994-03-22

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

562419, C07C 5116, C07C 4500

Patent

active

052966364

ABSTRACT:
A process for the preparation of 2,4,6-trimethylbenzoic acid of the formula I ##STR1## in which .alpha.-chloro-2,4,6-trimethylacetophenone is reacted with an alkali hydroxide solution and chlorine in the presence of a phase-transfer catalyst at a temperature ranging from 0.degree. to 150.degree. C. and a pressure ranging from 0.01 to 50 bar, and a process for the preparation of 2,4,6-trimethylbenzoic acid I, in which .alpha.-chloro-2.4.6-trimethylacetophenone of the formula II ##STR2## is reacted with 1,3,5-trimethylbenzene and chloroacetyl chloride in the presence of a catalyst at a temperature ranging from 0.degree. to 150.degree. C. and a pressure ranging from 0.01 to 50 bar, the catalyst used being an iron oxide.

REFERENCES:
patent: 3530189 (1970-09-01), Moegeli
patent: 5093529 (1992-03-01), Schmand
Fuson, Chem. Rev., 15, pp. 275-309 (1964).
Allinger, "Organic Chemistry," pp. 497-499 (1971).
Bokova et al., "Chloroacetylation of Fluorene", J. Org. Chem., pp. 1103-1105 (1969).
Deposited Doc. (1976) Viniti 3747-76.
Deposited Doc., (1973) Viniti 7429-73.

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