Preparation of 2-(2-fluoro-4-biphenylyl)propionic acid and corre

Details Preparation of 2-(2-fluoro-4-biphenylyl)propionic acid and corre Preparation of 2-(2-fluoro-4-biphenylyl)propionic acid and corre

1980-09-22

1983-02-01

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

562492, 570129, 204158HA, C07C12166, C07C 5108

Patent

active

043714730

ABSTRACT:
2-(2-fluoro-4-biphenylyl)propionic acid is prepared from 2-amino-4-methyl-biphenyl via a series of novel intermediates. In particular 2-amino-4-methylbiphenyl is converted to 2-fluoro-4-methylbiphenyl, the methyl group is brominated to form 2-fluoro-4-monobromomethylbiphenyl which is transformed into 2-(2-fluoro-4-biphenylyl)acetonitrile. This acetonitrile is then converted to flurbiprofen via the corresponding propionitrile or it may be converted into flurbiprofen via the intermediate ethyl-2-(2-fluoro-4-biphenylyl)-2-cyanopropionate.

REFERENCES:
patent: 3755427 (1973-08-01), Adams et al.
patent: 3959364 (1976-05-01), Armitage et al.
patent: 4036989 (1977-07-01), Armitage et al.

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