Preparation of 2,2-diorgano-3-arylpropionic acids and esters the

Details Preparation of 2,2-diorgano-3-arylpropionic acids and esters the Preparation of 2,2-diorgano-3-arylpropionic acids and esters the

1992-04-24

1993-01-12

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560105, 560 55, 560 51, 560 21, 560 9, 558406, C07C 5110

Patent

active

051792290

ABSTRACT:
A process for the preparation of 2,2-diorgano-3-arylpropionic acids is disclosed by the carbonylation of corresponding 2,2-diorgano-1-aryl ethanol in the presence of a Lewis acid catalyst. Furthermore, a process for the production of 2,2-diorgano-3-arylpropionic esters is disclosed by reacting a corresponding 2,2-diorgano-1-aryl ethanol with carbon monoxide and an alcohol in the presence of a Lewis acid catalyst.

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David E. Nichols, et al., "Effects of Certain Hallucinogenic Amphetamine Analogues on the Release of [.sup.3 H]Serotonin from Rat Brain Synaptosomes", J. Medicinal Chemistry25, 530-535 (1982).
Percy Warrick, Jr., et al., "The Migration Aptitude of Benzyl vs. in Methyl Carbonium Ion Reactions of the 2,2-Dimethyl-3-phenyl-1-propyl System"J. Am. Chem. Soc., 4095-4100 (Nov. 5, 1962).
Boyd E. Hudson, Jr., et al., "Condensations. XIII. The Alkylation of Ethyl Isobutyrate and of Certain other Esters by Means of Sodium Triphenylmethyl and Alkyl Halides", J. Am. Chem. Soc., 2457-2459 (Sep. 1940).

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