Preparation of 2-(2-arylmorpholin-2-yl) ethanol derivatives...

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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C544S106000

Reexamination Certificate

active

07378521

ABSTRACT:
The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives as well as intermediates therefor.

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Bose, D., et. al., (R)-3-N-Benzyl-5-Vinyl-Oxazolidin-2-One, Synth. Commun., vol. 19, No. 19, (1989) pp. 3313-3322.
Takahide, N., et. al., An Efficient Synthesis of Enantiomerically Pure 2-[(2R)-Arylmorpholin-2-yl]Ethanols, Key Intermediates of Tachykinin Receptor Antagonist, Tetrahedron: Asymmetry vol. 9, (1998) pp. 3251-3262.
Nishi, T., et. al., New Heterocyclic Compounds for Treating Alergy and Urinary Incontinence, see Derwent Patent Abstract No. 199931 (2001).
Van Houten, K.A., et. al., A New Strategy for the Design of Monoamine Oxidase Inactivators, Exploratory Studies with Tertiary Allylic and Propargylic Amino Alcohols, J. Am. Chem. Soc. (1998) vol. 120, pp. 5864-5872.
Beilstein Informationssysteme GmbH Abstract No. XP002150501, 1989.

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