Preparation of 1H-imidazo[4,5-C] quinolin 4-amines via novel...

Details Preparation of 1H-imidazo[4,5-C] quinolin 4-amines via novel... Preparation of 1H-imidazo[4,5-C] quinolin 4-amines via novel...

2007-01-23

2007-01-23

Aulakh, Charanjit S. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S080000, C546S079000

Reexamination Certificate

active

11009259

ABSTRACT:
The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C] quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C] quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-carboxamide, and to the said intermediates.

REFERENCES:
patent: 4689338 (1987-08-01), Gerster
patent: 4689388 (1987-08-01), Hirai et al.
patent: 4698348 (1987-10-01), Gerster
patent: 4988815 (1991-01-01), Andréet al.
patent: 5238944 (1993-08-01), Wick et al.
patent: 5367076 (1994-11-01), Gerster
patent: 5395937 (1995-03-01), Nikolaides et al.
patent: 5578727 (1996-11-01), Andre et al.
patent: 5602256 (1997-02-01), Andréet al.
patent: 5756747 (1998-05-01), Gerster
patent: 6841678 (2005-01-01), Merli et al.
patent: 0 145 340 (1985-06-01), None
patent: 0 145 340 (1985-06-01), None
patent: 0 310 950 (1989-04-01), None
patent: 0 310 950 (1989-04-01), None
patent: 0 385 630 (1990-09-01), None
patent: 0 385 630 (1990-09-01), None
patent: 0 385 630 (1990-09-01), None
patent: 1256582 (2002-11-01), None
patent: 4-193866 (1992-07-01), None
patent: WO 92/06093 (1992-04-01), None
patent: WO 92/15581 (1992-09-01), None
patent: WO 97/48704 (1997-12-01), None
patent: WO 01/58900 (2001-08-01), None
patent: WO 03/097641 (2003-11-01), None
R.T. Morrison et al., NY University, “Organic Chemistry, 6thEd.” p. 838-843, (1992) Prentice Hall, New Jersey.
R.C. Elderfield, University of Michigan, “Heterocyclic Compounds”, vol. 4, Quinoline, Isoquinoline, and Their Benzo Derivatives, New York—John Wiley & Sons, Inc., London—Chapman & Hall, Limited, p. 243 (1952).

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