Preparation of 14-hydroxynormorphinones from normorphinones

Details Preparation of 14-hydroxynormorphinones from normorphinones Preparation of 14-hydroxynormorphinones from normorphinones

1998-07-16

1999-09-14

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546 45, 546 46, C07D41300, C07D47100

Patent

active

059524952

ABSTRACT:
A process is provided for preparing 14-hydroxynormorphinones having the formula: ##STR1## which comprises reacting normorphinones having the formula: ##STR2## wherein R is selected from the group consisting of lower alkyl of 1 to 7 carbon atoms, cycloalkyl-lower alkyl with 3-6 ring carbon atoms, benzyl and a substituted-benzyl having the formula: ##STR3## wherein Q and Q.sup.1 are individually selected from the group consisting of hydrogen, lower alkyl, trifluoromethyl, nitro, dialkylamino and cyano;

REFERENCES:
patent: 3819636 (1974-06-01), Wiesner
patent: 4668685 (1987-05-01), Shami
patent: 4912114 (1990-03-01), Revesz
Hosztafi et al, Chemical Abstract vol. 109 No. 129415, "Prep. of N-Dimethyl-14-Hydroxy-Dihydromorphines der as Pharm." (1988).
Hussain et al, Chemical Abstract vol. 107 No. 120962, "Improvement of the Oral Hoansbility of Naltrexone in Days," (1987).

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