Preparation of 14-hydroxynormorphinones from normorphinone dieno

Details Preparation of 14-hydroxynormorphinones from normorphinone dieno Preparation of 14-hydroxynormorphinones from normorphinone dieno

1997-07-11

1999-02-09

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48908

Patent

active

058696695

ABSTRACT:
The invention provides processes for the conversion of normorphinone and its derivatives, which can be synthesized from morphine, to the corresponding 14-hydroxynormorphinone and its derivatives including oxycodone, oxymorphone, noroxymorphone and naltrexone. Noroxymorphone is a key intermediate for the production of important narcotic analgesics and antagonists. The invention also provides certain novel intermediates.

REFERENCES:
patent: 4668685 (1987-05-01), Shami
patent: 4795813 (1989-01-01), Schwartz
patent: 5112975 (1992-05-01), Wallace

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