Preparation of 11-deoxy anthracycline antibiotics

Details Preparation of 11-deoxy anthracycline antibiotics Preparation of 11-deoxy anthracycline antibiotics

1979-10-05

1982-01-05

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435172, 435253, 536 17A, 424181, C12P 1956

Patent

active

043095038

ABSTRACT:
Anthracycling antibiotics of the formula: ##STR1## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 having antitumor and antibacterial activity are prepared by culturing a new mutant strain of microorganism designated as Macromonospora peucetica sp. nova and which has been deposited with the American Type Culture Collection under numbr No. 31366 ATCC.

REFERENCES:
Lamanna et al., Basic Bacteriology, Its Biological and Chemical Background, The Williams & Williams Co., pp. 723-727 (1965).
Metzler, Biochemistry, The Chemical Reactions of Living Cells, Academic Press pp. 945 & 946 (1977).

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