Preparation of 1-N-[.omega.-amino-.alpha.-hydroxyalkanoyl]aminog

Details Preparation of 1-N-[.omega.-amino-.alpha.-hydroxyalkanoyl]aminog Preparation of 1-N-[.omega.-amino-.alpha.-hydroxyalkanoyl]aminog

1980-10-01

1982-08-31

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 12, 536 17R, C07H 1522

Patent

active

043473547

ABSTRACT:
An improved process for the preparation of 1-N-[.omega.-amino-.alpha.-hydroxyalkanoyl]aminoglycoside antibiotics comprises acylating a polysilylated aminoglycoside antibiotic in a substantially anhydrous organic solvent with an acylating derivative of an .omega.-amino-.alpha.-hydroxyalkanoic acid.

REFERENCES:
patent: 4029882 (1977-06-01), Wright
patent: 4029883 (1977-06-01), Hiraga et al.
patent: 4055715 (1977-10-01), Tomioka et al.
Tsuchiya et al., "Tetrahedron Letters", No. 51, pp. 4951-4954.
Cron et al., "ACS Symposium Series #125 Amino Cyclitol Antibiotics", Amer. Chem. Soc., Washington, D.C., 1980, pp. 247-254.

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