Preparation of 1-(lower alkyl)-1,4-dihydro-7-methyl-4-oxo-1,8-na

Details Preparation of 1-(lower alkyl)-1,4-dihydro-7-methyl-4-oxo-1,8-na Preparation of 1-(lower alkyl)-1,4-dihydro-7-methyl-4-oxo-1,8-na

1974-06-10

1976-06-15

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D47104

Patent

active

039637360

ABSTRACT:
A process for producing a compound of the formula: ##SPC1##
Wherein Z is CH or N; R is a lower alkyl group, a lower alkenyl group, a cycloalkyl group or a hydroxyalkyl group; R.sub.1 is a hydrogen atom or lower alkyl group; when Z is N, R.sub.2, R.sub.3 and R.sub.4 are a hydrogen atom, a halogen atom a lower alkyl group, a lower alkoxyl group, a lower hydroxyalkyl group, a lower acyloxyalkyl group, trihalogenoalkyl group, a carboxyl group, a cyano group, or an aralkyl group; when Z is CH, R.sub.2, R.sub.3 and R.sub.4 are a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxyl group, a trihalogenoalkyl group, a cyano group, a nitro group, an alkylmercapto group, a lower alkylenedioxy group, or a lower alkylene bridge attached to the quinoline nucleus, which comprises heating a compound of the formula ##SPC2##
Wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Z are as defined above, followed, if desired, by hydrolyzing the product obtained, is disclosed.
The product is useful as an antibacterial agent. An intermediate having the formula: ##SPC3##
Wherein A is OR or a halogen atom, and R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Z are as defined above, and a process for its preparation are also disclosed.

REFERENCES:
patent: 3673193 (1972-06-01), Lesher et al.
patent: 3855232 (1974-12-01), Brundage et al.

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