Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins

Details Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins

1987-03-26

1989-12-26

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Esterification of the 3-position -cx- group, wherein the x's...

540336, 540338, C07D49908

Patent

active

048899291

ABSTRACT:
Process for the preparation of 1'-ethoxy carbonyloxy ethyl esters of penicillins, wherein a compound of the formula ##STR1## in which A is phenyl, phenoxy or 4-hydroxyphenyl, B is hydrogen, an amino group or a protected amino group and Z is hydrogen or a cation selected from the group of alkali metal, tri (lower alkyl ) ammonium and tetra (lower alkyl) ammonium, is reacted with 1-bromoethyl ethyl carbonate in an organic solvent and when B is a protected amino group the protecting group is split off to yield a primary amino group.
There are also provided novel compounds of the formula ##STR2## in which Ph is phenyl and R is CH.sub.3 -- or C.sub.2 H.sub.5 --.

REFERENCES:
patent: 3697507 (1972-10-01), Fredericksen et al.
patent: 3873521 (1975-03-01), Ekstrom et al.
patent: 4342772 (1982-08-01), Godtfredsen et al.

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