Preparation of 1-alkyl- or 1-cycloalkylpiperazines

Details Preparation of 1-alkyl- or 1-cycloalkylpiperazines Preparation of 1-alkyl- or 1-cycloalkylpiperazines

1985-10-24

1988-04-05

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544358, 544403, 544404, C07D40504, C07D29502

Patent

active

047360305

ABSTRACT:
1-Alkyl- or 1-cycloalkylpiperazines are prepared by reacting piperazine with an alkanol or cycloalkanol in the presence of hydrogen and a hydrogenation/dehydrogenation catalyst by a process in which the reaction is carried out at from 130.degree. to 190.degree. C. under from 5 to 100 bar in the presence of from 5 to 40% by weight, based on the reaction mixture, of water, and the molar ratio of piperazine to alkanol or cycloalkanol is kept at from 1:1.5 to 1:8.

REFERENCES:
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patent: 4152353 (1979-05-01), Habermann
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patent: 4267175 (1981-05-01), Watts
Baltzly et al., JACS, vol. 66, pp. 263-266.
Dockner et al., Chem. Abst., 79-115626g.
W. Gelger and H. Rase, Useful Products from Piperazine, Methylpiperazines and an Amorphous Dibasic Acid/Piperazine Polymer, Ind. Eng. Chem. Prod. Res. Dev., 1981, 20, 688-693.
Journal of Organic Chemistry, 21, 86, (1956).

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