Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-04-29
2008-04-29
Jiang, Shaojia Anna (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S123100, C514S054000, C514S061000, C564S462000
Reexamination Certificate
active
10519519
ABSTRACT:
The present invention provides a preparation method of valienamine from acarbose or acarbose derivatives using organic acid TFA (trifluoroacetic acid). By using the method of the present invention, valienamine, the core precursor of voglibose which is a strong retardant of α-glucosidase and which is used for the cure of diabetes, can be produced in large quantities by using selective hydrolysis from acarbose or acarbose derivatives using TFA.
REFERENCES:
patent: WO 2004000782 (2003-12-01), None
Tatsuta, Kuniaki, Mukai, Hiroshi and Takahashi, Masaaki, “Novel Synthesis of Natural Pseudo-aminosugars, (+)-Valienamine and (+)-Validamine”, The Journal of Antibiotics, vol. 53 No. 4, pp. 430-435, Apr. 2000.
Yoshikawa, Masayuki, Cha, Bae Cheon, Okaichi, Yoshihiko, Takinami, Yoshihiko, Yokokawa, Yoshihiro and Kitagawa, Isao, “Syntheses of Validamine, EPI-Validamine, and Valienamine, Three Optically Active Pseudo-Amino-Sugars, From D-Glucose”, Communications to the Editor, Chem. Pharm. Bull, vol. 36, pp. 4236-4239, 1988.
Her Youl
Oh Jin-Hwan
B T Gin, Inc.
Barlow Josephs & Holmes, Ltd.
Henry Michael C.
Jiang Shaojia Anna
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