Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2007-04-10
2008-05-13
Witherspoon, Sikarl A. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S567000
Reexamination Certificate
active
07371897
ABSTRACT:
Provided is a novel preparation method of (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid represented by the following formula (1), a key intermediate of cilastatin used as a supplement to imipenem. The novel preparation method of the invention produces a pure (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid, a key intermediate of cilastatin, by selective hydrolysis of E isomers.
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patent: 5147868 (1992-09-01), Graham et al.
patent: 2005/0119346 (2005-06-01), Kumar et al.
patent: WO2006022511 (2006-03-01), None
Graham et al. Inhibition of the Mammalian B-Lactamae Renal Dipeptidase (Dehydropeptidase-I) by (Z)-2-(Acylamino)-3-substituted- propenoic Acids. Journal of Medicinal Chemistry, 1987, vol. 30, pp. 1074-1090.
Cho Yang Rai
Jeong Seon Yi
Kim Byung Hwan
Koo Eon Cheol
Shim Young Ji
Coleman Henry D.
Sapone William J.
Sudol R. Neil
Wischem Co., Ltd.
Witherspoon Sikarl A.
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