Preparation having increased in vivo tolerability

Details Preparation having increased in vivo tolerability Preparation having increased in vivo tolerability

1998-05-13

2000-02-01

Lee, Howard C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 25, 514 42, 536 41, 536 64, 536 291, A61K 3170, C07H 506, C07H 15244

Patent

active

060203153

ABSTRACT:
A preparation having increased in vivo tolerability comprising a glycosyl-Y[--C(.dbd.Y)--X--].sub.p --W(R).sub.n --X--C(.dbd.Y)-active compound, sugar or sugar alcohol and, optionally divalent ions, and a pharmaceutically tolerable carrier.

REFERENCES:
patent: 5561119 (1996-10-01), Jacquesy et al.
patent: 5621002 (1997-04-01), Bosslet et al.
patent: 5710134 (1998-01-01), Bosslet et al.
Bosslet et al. "Fusion Protein-Mediated Tumor Selective Prodrug Activation" from Contributions to Oncology, (Eds. Huber & Queisser), vol. 48: 160-169, 1995.
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Bosslet et al. Cell Biophys., vol. 24/25: 51-63, 1994.
Haisma et al. Cell Biophys., vol. 24/25: 185-192, 1994.
Bosslet, Klaus, et al., "Tumor-selective Prodrug Activation by Fusion Protein-mediated Catalysis," Cancer Research, 54 (1994), pp. 2151-2159.
Gesson, J.P., et al., "Prodrugs of anthracyclines for chemotherapy via enzyme-monoclonal antibody conjugates," Anti-Cancer Drug Design, 9 (1994), pp. 409-423.
Houba, Pieter H.J., et al., "Characterization of Novel Anthracyline Prodrugs Activated by Human .beta.-glucuronidase for Use in Antibody-Directed Enzyme Prodrug Therapy," Biochemical Pharmacology, 52 (1996), pp. 455-463.
Leenders, Ruben G.G., et al., ".beta.-Glucuronyl Carbamate Based Pro-moieties Designed for Prodrugs in ADEPT," Tetrahedron Letters, 36 (1995), pp. 1701-1704.
Sinhababu, Anchintya K., et al., "Review Prodrugs of anticancer agents," Advanced Drug Delivery Reviews, 19 (1996), pp. 241-273.
Fiebig et al., Comparison of Tumor Response in Nude Mice and in the Patients, Behring Inst. Mitt., No. 74, pp. 343-352 (1984).

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