Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1991-11-26
1994-11-29
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424443, 424449, A61F 1302
Patent
active
053688600
ABSTRACT:
A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.
REFERENCES:
patent: 4655768 (1987-04-01), Marecki et al.
patent: 5120325 (1992-06-01), Dow, Jr.
Chemical Abstract, vol. 100, No. 2, p. 371 (1984).
Chemical Abstract, vol. 100, No. 2, pp. 306-307, (1984).
Eurpean Search Report, Nov. 26, 1992.
Hori Mitsuhiko
Kishi Ikuo
Maruyama Koji
Saito Kenichiro
Sunami Masaki
Horne Leon R.
Nitto Denko Corporation
Page Thurman K.
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