Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-04-08
2000-12-26
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
4284022, 424 943, A61K 9127
Patent
active
061655007
ABSTRACT:
The invention relates to a preparation for the application of agents in the form of minuscule droplets of fluid, in particular provided with membrane-like structures consisting of one or several layers of amphiphilic molecules, or an amphiphilic carrier substance, in particular for transporting the agent into and through natural barriers such as skin and similar materials. The preparation contains a concentration of edge active substances which amounts to up to 99 mol-% of the agent concentration which is required for the induction of droplet solubilization. Such preparations are suitable, for example, for the non-invasive applications of antidiabetics, in particular of insulin. The invention, moreover, relates to the methods for the preparation of such formulations.
REFERENCES:
patent: 4911928 (1990-03-01), Wallach
V.M. Knepp et al., "Controlled Drug Release from a Novel Liposomal Delivery System. II. Transdermal Delivery Characteristics" on Journal of Controlled Release 12(1990) Mar., No. 1, Amsterdam, NL, pp. 25-30. (Exhibit A).
C.E. Price, "A Review of the Factors Influencing the Penetration of Pesticides Through Plant Leaves" on I.C.I. Ltd., Plant Protection Division, Jealott's Hill Research Station, Bracknell, Berkshire RG12 6EY, U.K., pp. 237-252. (Exhibit B).
K. Karzel and R.K. Liedtke, "Mechanismen Transkutaner Resorption" on Grandlagen/Basics, pp. 1487-1491. (Exhibit C).
Michael Mezei, "Liposomes as a Skin Drug Delivery System" 1985 Elsevier Science Publishers B.V. (Biomedical Division), pp 345-358. (Exhibit E).
Adrienn Gesztes and Michael Mazei, "Topical Anesthesia of the Skin by Liposome-Encapsulated Tetracaine" on Anesth Analg 1988; 67: pp 1079-81. (Exhibit F).
Harish M. Patel, "Liposomes as a Controlled-Release System" on Biomecial Society Transactions 609th Meeting, Leeds, pp 513-516. (Exhibit G).
Philip G. Green, et al., "In Vitro and in Vivo Enhancement of Skin Permeation with Oleic and Lauric Acids" on International Journal of Pharmaceutics, 48 (1988), pp 103-111. (Exhibit H).
Guia M. Golden et al., "Role of Stratum Corneum Lipid Fluidity in Transdermal Drug Flux" on Journal of Pharmaceutical Sciences vol. 76, No. 1, Jan. 1987, American Pharmaceitucal Association, pp. 25-28. (Exhibit I).
Bruce J. Aungst et al., "Enhancement of Naloxone Penetration Through Human Skin in Vitro Using Fatty Acids, Fatty Alcohols, Surfactants, Sulfoxides and Amides" on International Journal of Pharmaceutics, 33(1986), pp 225-234. (Exhibit J).
Ronald R. Burnette et al., "Characterization of the Permselective Properties of Excised Human Skin During Lontophoresis" on Journal of Pharmaceutical Sciences vol. 76, No. 10, Oct. 1987, American Pharmaceutical Association, pp 765-773. (Exhibit K).
E.C. Katoulis et al., "Efficacy of a New Needleless Insulin Delivery System Monitoring of Blood Glucose Fluctuations and Free Insulin Levels" on International Journal of Artifical Organs vol. 12, No. 5, 1989, pp 333-338. (Exhibit L).
Ovais Siddiqui et al., "Nonparenteral Administration of Peptide and Protein Drugs" on CRC Critical Reviews in Therapeutic Drug Carrier Systems, vol. 3, Issue 3, pp 195-208. (Exhibit M).
Abstract searched from Derwent World Patents Index Latest. (Exhibit N).
Cevc, G. et al., "Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin", Biochimica et biophysica acta, 1368 pp. 201-215 (1998).
Cevc, G., "Material Transport Across Permeability Barriers by Means of Lipid Vesicles", Handbook of Biological Physics, vol. 1, pp. 465-490 (1995).
Mayer, L.D. et al., "Vesicles of variable sizes produced by a rapid extrusion procedure", Biochimica et Biophysica Acta, 858 pp. 161-165 (1986).
Patel, H. M. et al., "Oral Administration of Insulin by Encapsulation Within Liposomes", FEBS Letters, 62(1):60-63 (Feb. 1976).
Mayer BBA 858 (1986) p 161-168.
Patel FEBS Letters 62 #1, Feb. 1976, p 60.
Idea AG
Kishore Gollamudi S.
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