Preparation for percutaneous administration

Details Preparation for percutaneous administration Preparation for percutaneous administration

1985-08-14

1987-03-31

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Lymphokine

514 41, 514152, 514159, 514162, 514165, 514166, 514179, 514223, 514263, 514352, 514357, 514400, 514404, 514462, 514628, 514635, 514742, 514947, A61K 3179

Patent

active

046542094

ABSTRACT:
A preparation for percutaneous administration of nitroglycerine, said preparation comprising nitroglycerine incorporated in a cream base in an amount not less than about 0.05% by weight based on the total weight of the preparation. The composition may also contain other medicaments, the bioavailability of which is enhanced by the nitroglycerine. The action of the preparation against for example angina may be brought about by having an appropriate amount of nitroglycerine or as additional medicament another medicament active against angina. The preparation may contain an hydroxyalkylcellulose which may provide, in combination with a waxy component in the cream, for example a higher aliphatic alcohol, a prolonged release effect. The preparation has advantages particularly as regards bioavailability over prior uniphasic ointments.

REFERENCES:
patent: 3395215 (1968-07-01), Schubert
patent: 3551554 (1970-12-01), Herschler
patent: 3609102 (1971-09-01), Schussman
patent: 3789119 (1974-01-01), Fosari et al.
patent: 4197318 (1980-04-01), Sipos
patent: 4322433 (1982-03-01), Leslie et al.
patent: 4323577 (1982-04-01), Ohkuna et al.
Lachman et al-The Theory & Practice of Industrial Pharmacy, 2nd ed. (1976), pp. 215-244.
Kremers-Urban-"Nitrol" Ointment, package insert, 10/77, p. 1200.

Affiliated with

Also associated with

Rating

Preparation for percutaneous administration does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation for percutaneous administration, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation for percutaneous administration will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2212015