Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1985-02-19
1986-11-11
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
424 48, 424140, 424145, A61K 716
Patent
active
046222200
ABSTRACT:
A composition for oral hygiene with improved efficacy against dental plaque, said composition containing zinc aspartate and/or copper aspartate, preferably in an amount of 0.05 to 5% by weight based on the total weight of the composition.
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Kietzman C. A. 101 #190152A, (1984), of DTW 91(7/8): 273-6(1984) Oral Substitution of Zinc Deficit with Zinc Aspartate and Zinc Carbonate in Rats.
Hanke, Milton Theo., "Studies on the Local Factors in Dental Caries. I. Destruction of Plaques and Retardation of Bacterial Growth in the Oral Cavity", J. Amer. Den. Assn., vol. 27, No. (1940), pp. 1379-1393.
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Afseth, John, "Some Aspects of the Hynamics of Cu and Zn Retained in Plaque as Related to Their Effect on Plaque pH", Scand J. Dent Res. 1983, vol. 91, pp. 169-174.
Afseth, John, "Accumulation of Cu and Zn in Human Dental Plaque in Vivo", Caries Res. 17:310-314, (1983).
Saxer, U. P. et al, "Synergistic Antiplaque Effects of a Zinc Fluoride/Hexetidine Containing Mouthwash. A Review", HOA vol. 27; 1-16; Aug. 1983.
Afseth, John et al, "Effect of Copper Applied Topically or in Drinking Water on Experimental Caries in Rats", Caries Res. 18:434-39, (1984).
Blendax-Werke R. Schneider
Rose Shep K.
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