Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1994-02-14
1997-05-06
Krass, Frederick
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424499, A61K 948, A61K 972, A61K 914
Patent
active
056268718
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a preparation for intratracheobronchial administration. More specifically, the present invention relates to a preparation for intratracheobronchial administration, comprising a powder preparation for intratracheobronchial administration contained in a receptacle composed of at least one component selected from the group consisting of hydroxypropyl methyl cellulose, methyl cellulose, hydroxypropyl cellulose, starches, hydroxypropyl starches, and sodium alginate. Furthermore, specifically, the present invention is concerned with a preparation for intratracheobronchial administration, contained in a receptacle, in which a medicament in the powder preparation for intratracheobronchial administration is contained in the receptacle composed of at least one component of cellulose derivatives-analogues, that is, selected from the group consisting of hydroxypropyl methyl celluloses, methyl celluloses, hydroxypropyl celluloses, starches, hydroxypropyl starches, and sodium alginate, and the medicament is not easily adhered to the receptacle so that the amount of the intratracheobronchially delivered medicament is improved.
BACKGROUND ART
The airway extending from the nasal cavity, oral cavity to the pharynx, larynx, trachea, bronchia, bronchioles, and alveoli is a passageway for expiratory and inspiratory air.
In the airway, there occur many diseases such as nasal allergies, asthma, bronchitis, lung emphysema, and the like. The method for administering a medicament in the pharmacotherapy for these diseases may be classified into the whole body administration such as the use of orally administered medicaments and injections, and intratracheobronchial local administration such as the use of nebulas, inhalants, and the like.
Oral administration is an easy method, and the use of injections ensures the absorption of the injections into the body, and therefore, these administering methods have widely been employed. However, intratracheobronchial administration of a medicament is highly valuable in the light of convergence of the medicament into an acting site, reduction of adverse side effects due to the convergence, and fast-acting properties of the effect of the medicament.
Further, in addition to the local administration of a medicament for such diseases as mentioned above, which occur in the airway, there has recently been a trial of proceeding a medicament from alveoli to blood by utilization of the fact that the barrier between the alveoli and blood is dwarfish, and the intratracheobronchial administration has now attracted public attention as a systemic administration method for peptides, proteins or the like, which are metabolized in the gastrointestinal tract, liver or the like so as to be inactivated, when these are orally administered.
In addition, there have been attempts to locally administer a vaccine in the airway by utilizing the antigen recognizing function of the lymphatic system in the airway, so as to prevent and treat a disease. Therefore, it may be said that the importance of intratracheobronchial administration is very significant.
The preparations for intratracheobronchial administration to be used for the above intratracheobronchially administering method can be classified into the following two kinds, with respect to the properties of the particles of the preparations: (1) preparations, the droplets of which are deposited to the inside of the airway, and (2) preparations, the fine solid particles of which are deposited to the inside of the airway.
A preparation (1) is usually an aqueous solution containing a medicament, which is atomized by a nebulizer, and inhaled into the airway as minute droplets. Preparations (2) are further roughly classified into (i) aerosol preparations, in which the fine solid particles are contained in a pressure container in a state such that they are dispersed in a fluorohydrocarbon, and when they are discharged out of the vessel in the case of the use thereof, these particles move in the airway together with the fluo
REFERENCES:
patent: 3634582 (1972-01-01), Hartley et al.
patent: 4161517 (1979-07-01), Bell
patent: 4294829 (1981-10-01), Suzuki et al.
Kobayashi Hideki
Makino Yuji
Suzuki Yoshiki
Krass Frederick
Teijin Limited
LandOfFree
Preparation for intratracheobronchial administration does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation for intratracheobronchial administration, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation for intratracheobronchial administration will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2130601