Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Patent
1995-09-05
1998-09-01
Reamer, James H.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
424648, A61K 31715
Patent
active
058008357
DESCRIPTION:
BRIEF SUMMARY
DESCRIPTION
The invention relates to a preparation for stimulating the circulation of blood.
Stimulation of the circulation of the skin is a problem for whose solution a number of research results have already been disclosed and for which different paths have been followed. The influence of magnetic forces has also been increasingly studied, especially in recent years.
Among other things, the use of pulsed electromagnetic fields has been studied as a potentially useful therapy for the postoperative treatment of pain and oedema (Mayrovitz, H. N., Larsen, P. B., WOUNDS, vol. 4, no. 5, 197 (1992)).
Beauty Forum 2/93, page 46, has disclosed the use of a stick which the user rubs over the skin, a magnetic field having an effect on the skin surface. According to the manufacturer, cells which are no longer fully functional are supposed to be stimulated by a magnetic field, initiating a self-healing process and restoring firmness and elasticity to the skin.
The use of magnetic polymer particles, some of which have pharmacologically active compounds coupled to them, has also been described, e.g. in U.S. Pat. No. 4,501,726, U.S. Pat. No. 4,335,094 and U.S. Pat. No. 5,039,559. In these patent descriptions, soft ferrite particles or ferroaluminates were encapsulated with polymeric materials and introduced into the body.
A magnetic cosmetic preparation is described in JP-A-4-108710 (Yoko Shiga). Here ferromagnetic substances, e.g. magnetite or manganese zinc ferrite (all soft ferrites), are dispersed in a cosmetic preparation in the demagnetized state and the preparation is magnetized after cosmetic application to the skin. This form of application is said to have a circulation-stimulating effect, namely a 3.4% increase in circulation in animal experiments with a proportion of 0.1% of magnetite. The specification contains no further information.
The object of the invention is to provide a novel preparation with a substantially improved circulation-stimulating effect. According to the invention, the preparation for stimulating the circulation contains a pharmaceutically or cosmetically acceptable excipient and optionally conventional formulation additives, in which there are finely divided, magnetically hard single-domain particles with a strong coercive field and with sizes in the range 600 to 1200 nm.
The term "single-domain particles" is understood as meaning single crystals of naturally uniform magnetic orientation. Magnetically hard single-domain particles which are particularly preferred in the present invention are barium or strontium hexaferrites, which advantageously are not doped. These undoped barium or strontium hexaferrites are prepared by known processes, e.g. by growing single crystals from a tempered glass melt in accordance with the glass crystallization technique. A suitable glass for this purpose is the three-component system BaO--Fe.sub.2 O.sub.3 --B.sub.2 O.sub.3, which is advantageously composed of 20 to 50% by weight of Fe.sub.2 O.sub.3, 30 to 50% by weight of BaO and 20 to 50% by weight of B.sub.2 O.sub.3.
The diameter/thickness ratio of the crystals of barium hexaferrite or strontium hexaferrite is generally 3:1 to 10:1.
The sizes of the single-domain particles are preferably in the range 750 to 1000 nm and especially in the range 800 to 950 nm. In this range, the particles have a particularly advantageous, strong coercive field. The coercive field is advantageously in the range 3000 to 5000 Oersted and preferably in the range 4000 to 5000 Oersted, although it can also be higher.
The single-domain particles according to the invention can be dispersed very well in a pharmaceutically/cosmetically acceptable excipient and in additives by the conventional processes and there is only insignificant aggregation, if any, in the dispersion. This is particularly surprising because it is clear from all the publications of the state of the art that permanent-magnetic particles, i.e. magnetically hard particles, always tend to aggregate and therefore have to be incorporated into a dispersion with particular
REFERENCES:
patent: 5411730 (1995-05-01), Kirpotin et al.
Beauty Forum, Feb. 1993, S. 46.
Derwent Abstracts, EP 186,616 A--86-171,075/27, J 59116214 A--84203893/33, J 59139314 A--84-2339/39, and JO 209428 A--90-110377/15.
Golz Karin
Hulsenberg Dagmar
Stanzl Klaus
Zastrow Leonhard
Lancaster Group GmbH
Reamer James H.
LandOfFree
Preparation for improving the blood supply containing hard magne does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation for improving the blood supply containing hard magne, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation for improving the blood supply containing hard magne will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-267476