Drug – bio-affecting and body treating compositions – Dentifrices – Ferment containing
Patent
1991-08-01
1992-09-08
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
Ferment containing
424 49, 514 25, 514901, A61K 728, A61K 3748, A61K 3754
Patent
active
051456656
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to oral an dental care preparations containing polysaccharide-splitting enzymes and surfactants which do not damage these enzymes.
2. Statement of Related Art
Toothpastes, toothpowders and mouthwashes above all are used to care for the teeth, the gums and the oral cavity. These products normally contain surfactants to enhance the cleaning effect of the toothbrush and the abrasives present in toothpastes and toothpowders. In addition, oral and dental care preparations generally contain active substances for hardening the dental enamel and controlling tartar and plaque (bacterial coatings). It is known that dextrans, which are formed by bacterial polymerization from glucose, play an important part in the formation of plaque, so that it has repeatedly been proposed to add enzymes having a polysaccharide-splitting effect, particularly dextranase, to oral and dental care preparations to disrupt the mechanism responsible for the formation of plaque or to redissolve freshly formed coatings (cf. JADA, Vol. 82, Jan. 1971, 123-141, GB 1,202,629).
It is also known that many surfactants inhibit the effect of enzymes so that special surfactants more compatible with enzymes have already been proposed for use in oral and dental care preparations containing dextranase. According to GB 1,319,423, N-lauroyloxyethyl sulfoacetamide potassium salt is said to be compatible with dextranase. Many other patent applications propose stabilizing additives to protect the dextranase against damage by surfactants.
DESCRIPTION OF THE INVENTION
Objects of the Invention
The surfactants proposed hitherto, where they actually do show better compatibility with dextranase, have serious applicational disadvantages because foaming behavior is generally unsatisfactory or the wetting properties are inadequate. These disadvantages are largely eliminated by the oral and dental care preparations according to the invention.
SUMMARY OF THE INVENTION
The present invention relates to oral and dental care preparations containing (A) polysaccharide-splitting enzymes and (B) surfactants in an aqueous carrier, characterized in that alkylglycosides are present as the surfactants.
In the context of the invention, oral and dental care preparations are primarily understood to be toothpastes and mouthwashes containing an aqueous carrier. However, the preparations according to the invention also include toothpowders because toothpowders are regularly used with water and, accordingly, also require water as carrier component in use.
Polysaccharide-splitting enzymes are understood to be any carbohydrases which catalyze the enzymatic hydrolysis of carbohydate constituents. Enzymes such as these are obtained from microorganisms by known processes.
DESCRIPTION OF PREFERRED EMBODIMENTS
Examples of suitable enzymes are .alpha.- and .beta.-glucosidas-es, .alpha.- and .beta.-galactosidase, .alpha.- and .beta.-amylase, glucoamylase (.alpha.-1,4-glucanglucohydrolase), cellulase, saccharase, mutanase and dextranase. It is particularly preferred to use dextranase (1,6-.alpha.-D-glucan-6-glucanohydrolase) and/or 1,3-glucanase as the polysaccharide-splitting enzyme.
Alkylglycosides, their production and their use as surfactants are known, for example, from U.S. Pat. Nos. 3,839,318, 3,707,535 and 3,547,828, DE-A-1,943 689, DE-A-2 036 472 and DE-A-3 001 064 and from EP-A-77 167. They are produced in particular by reaction of glucose or oligosaccharides with primary C.sub.8-22 alcohols. So far as the glycoside part is concerned, both monoglycosides, in which a cyclic sugar residue is attached to the fatty alcohol by a glycosidic bond, and oligomeric glycosides having a degree of polymerization of preferably up to 10 are suitable. Preferred alkylglycosides for the production of the preparations according to the invention are those corresponding to the general formula RO--(C.sub.6 H.sub.10 O.sub.5).sub.x --H, in which R is an aliphatic radical of a primary C.sub.8-22 fatty alcohol and --(C.sub.6 H.s
REFERENCES:
patent: 4748158 (1988-05-01), Bierman et al.
patent: 4920100 (1990-04-01), Lehmann et al.
patent: 4923685 (1990-05-01), Wuelknitz et al.
Klueppel et al GA. 114(12): 108726c (1990) of PCT/WO 9008532 Aug. 9, 1990.
Wuelknitz et al GA. 115(6): 56974F (1991) of EP 414128 Feb. 27, 1991.
Sasaki et al GA. 111(18): 160022x (1989) of JPN 01068312 Mar. 14, 1989.
Wuelknitz et al. GA. 111(16): 1405245 (1989) of GER Off. DE 3725248 Feb. 9, 1989.
Biermann et al CA. 105(11): 94432D (1986) of Ger. Off DE 3444958 Jun. 12, 1986.
Foerg Franz
Klueppel Hans-Juergen
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Rose Shep K.
Szoke Ernest G.
Wisdom, Jr. Norvell E.
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