Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1980-11-03
1983-03-22
Phillips, Delbert R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424177, C07G 700, A61K 3700
Patent
active
043775110
ABSTRACT:
The present invention relates to immunopharmacology and, more specifically, to a preparation controlling the T-system of immunity and to a method for producing the same.
The preparation controlling the T-system of immunity is characterized by its content as the active principle, peptides with a molecular mass of from 1,500 to 6,000 Dalton having absorption maximum in UV-light at 280 and 275 nm and electrophoretic mobility in a polyacrylamide gel relative to bromophenol blue: 0.062-0.102; 0.156-0.236; 0.354-0.374; 0.382-0.422; 0.432-0.472; 0.485-0.545; 0.850-0.930.
The method for producing the preparation according to the present invention comprises homogenization of a tissue of thymus gland in a solution of sodium chloride; the homogenizate is kept for 12-16 hours at a temperature of from 2.degree. to 6.degree. C., the residue is removed, thermolabile proteins are removed from the solution, peptides and proteins are precipitated and then dissolved and peptides are salted-out from the solution successively in three stages, the residue of peptides is removed, ultrafiltered through a membrane with a rated retention limit relative to globular proteins of from 12,000 to 30,000, the ultrafiltrate is gel-chromatographed to isolate peptides with a molecular mass of from 1,500 to 6,000 Dalton, desalted and lyophilized.
This preparation is used for the treatment of primary and secondary immunodeficient states, diseases caused by malignant neoplasms, psoriasis and other pathological states.
REFERENCES:
patent: 4002740 (1977-01-01), Goldstein et al.
patent: 4010148 (1977-03-01), Goldstein
patent: 4079127 (1978-03-01), Goldstein et al.
patent: 4120951 (1978-10-01), Goldstein
patent: 4128637 (1978-12-01), Naylor et al.
patent: 4239498 (1980-12-01), Rule
J. of Immunology 117, No. 1, (1976), 313-318.
Khaw, et al., Br. J. Cancer, (1973), 28, 288-292.
Miller, et al., Annals New York Academy of Science, 54-60.
Miller, et al., J. of Immunology 111, (1973), 1005-1009.
Goldstein, et al., Biochemistry, (1966), 1010-1017, vol. 56.
Nathenson, et al., Microbiology 56, 1966, 476-483.
Assaker, et al., Immunology 5158.
Annals New York Academy of Sciences, 234-240.
Goldstein, Triangle, vol. 11, No. 1, (1972), 7-14.
Goldstein, The Lancet, (1968), 119-122.
Goldstein, Nature 247, (1974), 11-14.
Chem. Abstr. 75, 1971, 2264m.
Chem Abstr. 74, 1971, 74202s.
Chem. Abstr. 74, 1971, 107464i.
Chem. Abstr. 67, 1967, 89620f.
Chem. Abstr. 67, 1967, 9611r.
Chem. Abstr. 73, 1970, 75216r.
Chem. Abstr. 73, 1970, 128537e.
Chem. Abstr. 82, (1975), 52001p.
Chem. Abstr. 82, 1975, 168226v.
Chem. Abstr. 83, 1975, 76888e.
Chem. Abstr. 81, 1974, 48075c.
Chem. Abstr. 92, 1980, 213364h.
Chem. Abstr. 92, 1980, 116412q.
Chem. Abstr. 81, 1974, 75518f.
Chem. Abstr. 87, 1977, 83044n.
Chem. Abstr. 80, 1974, 131090d.
Chem. Abstr. 79, 1973, 61811t.
Chem. Abstr. 87, 1977, 199009j.
Chem. Abstr. 93, 1980, 62101n.
Arion Vitaly Y.
Breusov Jury N.
Gladysheva Tatyana V.
Ivanushkin Evgeny F.
Kirzon Serafima S.
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