Preparation comprising thiol-group-containing proteins

Details Preparation comprising thiol-group-containing proteins Preparation comprising thiol-group-containing proteins

1998-01-16

2000-09-26

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 533350, 533324, A61K 3800, A01N 3718, C07K 100

Patent

active

061242551

ABSTRACT:
There is disclosed a stable, virus-safe, pharmaceutical preparation comprising thiol-group-containing proteins which are heat-treated and processed such that at least 40% of the thiol groups are capable of being nitrosated, a method of preparing such preparations as well as the use of these preparations.

REFERENCES:
E. Katchalski et al., "The Available of the Disulfide Bonds of Human and Bovine Serum Albumin and of Bovine .gamma.-Globulin to Reduction by Thioglycolic Acid", J. Am. Chem. Soc., vol. 79, pp. 4096-4099, 1957.
E. DeMaster et al., "Reaction of Nitric Oxide with the Free Sulfhydryl Group of Human Serum Albumin Yields a Sulfenic Acid and Nitrous Oxide", Biochemistry, 1995, 34:11494-11499.
B. Saville, "A Scheme for the Colorimetric Determination of Microgram Amounts of Thiols", Analyst, vol. 83, 1958, pp. 670-672.
G. Ellman, "Tissue sulfhydryl Groups", Archives of Biochemistry and Biophysics, 82:70-77 (1959).
J.S. Stamler et al., "S-Nitrosylation of Proteins with Nitric Oxide: Synthesis and Characterization of Biologically Active Compounds", Proc. Natl. Acad. Sci. USA, vol. 89, Jan. 1992, pp. 444-448.
G. Schlag et al., "Shock, Sepsis, and Organ Failure--Nitric Oxide", Fourth Wiggers Bernard Conference 1994, pp. 310-321.
Y. Zhang et al., "Nitrosation of Tryptophan Residue(s) in Serum Albumin and Model Dipeptides", The Journalof Biological Chemistry, vol. 271, No. 24, Jun. 1996, pp. 14271-14279.

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